nephroprotective effects of feijoa sellowiana leaves extract on renal injury induced by acute dose of ecstasy (mdma) in mice

objective(s): because of the high total phenolic contents of feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (mdma) treated mice.   materials and methods: animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of f. sellowiana leaves, intra-peritoneally. after one hour, an acute administration of mdma (20 mg/kg, ip) was injected. nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. histopathological study was also used.   results   : both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (p <0.05). not statistically significant was observed in effect of two extracts (p>0.05). a decrease in urea/ creatinine ratio was observed following aqueous extract treatment. methanolic extract showed higher activity in increasing kidney glutathione (p conclusion:   f. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of mdma in mice.